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KMID : 0358920030300010061
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Journal of the Korean Academy of Pedodontics
2003 Volume.30 No. 1 p.61 ~ p.68
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ANTIBODY PRODUCTION BY PARENTERAL ADMINISTRATION OF STREPTOCOCCUS MUTANS AND GLUCOSYLTRANSFERASE IN MICE
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Chang Mee-Young
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Abstract
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Streptococcus mutans is known to be a major causative organism of human dental caries. The development of a vaccine against dental caries involves identification of appropriate antigens of mutans streptococci against which protective immune responses can be mounted, and the selection of a method of immunization that will generate sustained levels of protective antibodies. Antigens receiving most attention include streptococcal surface proteins that are involved in attachment to tooth surfaces and glucosyltransferases (GTF) that synthesize adhesive glucans from sucrose. The induction of antibody responses to orally administered antigens is often difficult due to digestive destruction of antigens and immune tolerance. Here we report the induction of antibody responses to an anti-caries vaccine containing retinoic acid (RA). Subcutaneous immunization with formalin-fixed bacteria or GTF supplemented with RA induced higher serum IgM and IgA responses to GTF compaired to oral adminstration. Antisera induced by Ingbritt strain showed partial cross-reaction with LM-7 strain, but not with OMZ175. These results suggest that subcutaneous immunization with GTF combined with an immunomodulator, RA, may be applied to anti-caries vaccine.
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KEYWORD
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Streptococcus mutans, Glucosyltransferase(GTF), Retinoic acid, IgA
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